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This paper estimates the impacts of doctor crackdowns on the quantity demanded of prescription opioids, across-market substitution, and across-product substitution. Exploiting plausibly exogenous variation in the timing and location of administrative actions, I find that cracking down on a single doctor decreases county-level opioid dispensing by 10%. This decline persists across space and grows over time. Additionally, significant heroin substitution occurs, yet overall overdose mortality decreases. These results highlight a critical tradeoff policymakers should consider with targeted crackdowns: reductions in the flow of new users must be balanced against the harm that arises when existing users substitute to more
dangerous drugs.
